REGENHU | Bioprinting for Tissue Models, Oral Dose Formulation and Drug Discovery
We provide versatile and fully customizable bioprinting platforms for our customers' application needs, combining multiple printing technologies in a single 3D ...
Bioprinter R-GEN 100&200
Tabletop Bio Printer "R-GEN 100"
The R-GEN 100 3D printer is designed for highly accurate and repeatable printing of multiple materials during one print run. Combining up to five print tools with thermal control, different print technologies or multiples of the same print tool can be installed in one instrument. This provides the user with greater flexibility to print from single paste formulations or direct from powder without the need for intermediate products, ensuring weight reproducibility, disintegration times and friability conditions.
ERGONOMICS
- Facilitated cartridge filling and replacement
- Easy change of workzones
- Reduced cross-contamination with cleaning and purging station
- Real-time parameter adjustment with a modern instrument interface
(1) MULTIPLE TECHNOLOGY COMBINATIONS
- 6 dispensing technologies available
- 5 printhead tools slots
- Independent temperature control for each printhead tool
- Full workzone coverage
- Quick release clip for seamless cartridge filling.
(2) CALIBRATIONS AND MONITORING SYSTEM
- Contactless needle offset calibration
- Substrate height calibration option
- Process supervision system
(3) ADDITIONAL OPTIONS AND KITS
- Physical crosslinking
- Cartridge stirring system
- Integrated cleaning and purging station for tool cleaning
(4) PROCESS FLEXIBILITY
- Layer by layer
- Support materials
- FRESH for complex structure
(5) OPTIMIZED WORKZONES
- Standard work zone
- Electrospinning and writing
- Physiologically temperature controlled (5-40°C)
- High temperature controlled (RT to 80°C) work zones available
Bioprinting Station R-GEN 200
The R-GEN 200 bioprinting station is designed for printing cellular constructs, thanks to its biosafety enclosure and physiological temperature-controlled working zone.
Three printing technologies, supplied with the R-GEN 200 bioprinting station, which are each separately temperature controlled, provide a range of printing options, whether dispensing cell laden biomaterials at physiological temperature, or basal layer materials, such as laminin/entactin that require cooling to improve dispensing and deposition performance.
ERGONOMICS
The R-GEN Series bioprinters have been designed for ease of use, using experience gathered from years of interactions with our customers.
It offers work height adjustments, clear sterile and easy to clean work environment, facilitated cartridge filling and replacement, easy change of workzones, reduced cross-contamination with cleaning and purging station and real-time parameter adjustment with a modern instrument interface.
(1) MULTIPLE TECHNOLOGY COMBINATIONS
- 6 dispensing technologies available
- 5 printhead tools attachment slots
- Independent temperature control for each printhead tool
- Full work zone coverage
- Quick release clip for seamless cartridge filling
- High cell viability printing
(2) CALIBRATIONS AND MONITORING SYSTEM
- Contactless needle offset calibration
- Substrate height calibration option
- Process supervision system
(3) ADDITIONAL OPTIONS AND KITS
- Physical crosslinking
- Cartridge stirring system
- Integrated cleaning and purging station for tool cleaning
(4) INTEGRATED CLASS II BIOSAFETY ENCLOSURE
- Ergonomic design
- Control outside biosafety enclosure
- Easy to clean work area
(5) PROCESS FLEXIBILITY
- Layer by layer
- Support materials
- FRESH for complex structure
(6) EXCHANGEABLE WORKZONES
- Standard workzone
- Electrospinning and writing
- Physiologically temperature controlled (5-40°C)
- High temperature controlled (RT to 80°C)
(7) Cartridge Temperature Control
Control physiological temperature (5-40°C) for optimized bio-environment and material conditioning
(8) Pneumatic Strand Dispenser
Printing scaffolds or continuous strands of medium to high viscous materials
(9) Pneumatic Melt Dispenser
Printing thermoplastics with melting point up to 250°C and medium to high viscous material
(10) Volumetric Strand Dispenser with built-in temperature control
Controlled and precise deposition of non-homogeneous viscous material
(11) Pneumatic Drop Dispenser
Precision volume jetting of cell-laden droplets and low – medium viscous material deposition
Specification of Bioprinter R-GEN 100&200
| Product Name | R-GEN 100 | R-GEN 200 |
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| Description | Tabletop configurable 3D bioprinter with process interaction and technology convergence. | Biosafe configurable 3D bioprinting station with process interaction and technology convergence. |
| Base Instruments | A tabletop bioprinter, accommodating up to five printing tools with individual temperature control capability, vacuum sample mounting system, four different printing workzones with temperature control options, needle and substrate calibration systems, a process supervision system, and light curing for in-process material crosslinking. | A biosafety-enclosed 3D bioprinter, accommodating up to five printing tools with individual temperature control capability, vacuum sample mounting system, four different printing workzones with temperature control options, needle and substrate calibration systems, process supervision system and light curing for in-process material crosslinking. |
| Work zone | All print tools able to reach full extent of printing workzone. Max build zone: 130 x 90 x 65 mm |
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| Control Software | Live process interaction with R-GEN CONTROLLER (e.g. parameter changing, process interruption). | |
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| Instrument Compatibility | Ready-to-use tools Compatible with Pneumatic Strand Dispenser, Pneumatic Drop Dispenser, Pneumatic Melt Dispenser and Volumetric Strand Dispenser. |
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| Workzones | Compatible with Standard Workzone Kit, Physiological Temperature Kit, High Temperature Kits and Electrospinning and Writing Kit. | |
| Options | Compatible with Light Curing Kit and Process Supervision System | |
| Design Software | Compatible with SHAPER planning software for 2D/3D design and bioprinting process and protocol management | |
| Third-party products | Compatible with Liquid Temperature Control Unit for cartridges and workzone temperature control | |
Design and Planning Software SHAPER
SIMPLIFY YOUR PROTOCOL DEFINITION AND EXPERIMENT DESIGN DEVELOPMENT INTUITIVE AND EASY-TO-USE SOFTWARE
User-friendly and intuitive software which designs and combines 2D and 3D constructs and defines your printing protocol, converging various printing technologies and biomaterials.
COMPREHENSIVE PRINTING PLANNING : Benefit from complete and easy control of your printing process, from the design of your constructs to the definition of your printing sequence.
TIME SAVING : Drastically reduce the learning curve and design time thanks to biodesign features, such as automatic in-fill of complex structure, reuse of existing models and multi-object management on labware.
| Product Name | SHAPER PLANNING SOFTWARE FOR 2D/3D DESIGN AND BIOPRINTING PROCESS AND PROTOCOL MANAGEMENT |
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| Version | 1.0 |
| License | 3, 5 or 10 licenses including updates, bug-fixes and Help Hotline access. Dongle-based license (USB) allowing remote and on-site design work. |
| Compatibility | R-GEN 100 and R-GEN 200 Series bioprinting instruments. |
| Hardware & OS | Windows 10 64-bit |
| System RAM | 8 GB (minimum), 16 GB (recommended) |
| Hard Disk Storage | 512 Gb SSD (recommended) |
| CPU | Minimum: Intel Core i7-4500U, 64-bit, 1.80 GHz (3.00 GHz Turbo), 4 MB cache, 2 cores, 4 threads. Recommended: Intel Core i7-9850H, 64-bit, 2.60 GHz (4.60 GHz Turbo), 12 MB cache, 6 cores, 12 threads. |
| Supported 2D/3D files format | *.STL |
| Additional HW | 1 free USB port available, mouse and keyboard |
Application
SKIN MODELS
Create the complexity of human skin printing through a standardized, reproducible and automated 3D fabrication process.
Our expertise can help you achieve a highly physiologically-relevant skin model to scale.
TABLET FORMULATION
Our 3D printers are designed to develop research into complex drug formulation and delivery challenges. This includes altering tablet architecture to control release rates, and producing personalized medicines by tailoring therapeutic treatment dosages to better address a patient’s specific needs through combining multiple active components into a single solid form dose.
CELLULAR DRUG DISCOVERY MODELS
Using 3D bioprinters can create physiologically-relevant cellular disease models to test therapeutic hypothesis by accurately and reproducibly controlling the deposition of different cell types and support materials, providing a viable technology solution for drug discovery projects. Our scientific advisors are best placed to provide further information.
Recent Scientific Publication
| Author | Title | Year | Journal/Proceeding |
|---|---|---|---|
| Daghrery, Arwa and Ferreira, Jessica A. and de Souza Araújo, Isaac J. and Clarkson, Brian H. and Eckert, George J. and Bhaduri, Sarit B. and Malda, Jos and Bottino, Marco C. | A Highly Ordered, Nanostructured Fluorinated CaP-Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration[Abstract] | 2021 | Advanced Healthcare Materials |
| Habelt, Bettina and Wirth, Christopher and Afanasenkau, Dzmitry and Mihaylova, Lyudmila and Winter, Christine and Arvaneh, Mahnaz and Minev, Ivan R. and Bernhardt, Nadine | A Multimodal Neuroprosthetic Interface to Record, Modulate and Classify Electrophysiological Biomarkers Relevant to Neuropsychiatric Disorders | 2021 | Frontiers in Bioengineering and Biotechnology |
| Bouwmeester, Manon C. and Bernal, Paulina N. and Oosterhoff, Loes A. and van Wolferen, Monique E. and Lehmann, Vivian and Vermaas, Monique and Buchholz, Maj-Britt and Peiffer, Quentin C. and Malda, Jos and van der Laan, Luc J. W. and Kramer, Nynke I. and Schneeberger, Kerstin and Levato, Riccardo and Spee, Bart | Bioprinting of Human Liver-Derived Epithelial Organoids for Toxicity Studies | 2021 | Macromolecular Bioscience |
| Ng, Wei Long and Ayi, Teck Choon and Liu, Yi-Chun and Sing, Swee Leong and Yeong, Wai Yee and Tan, Boon-Huan | Fabrication and Characterization of 3D Bioprinted Triple-layered Human Alveolar Lung Models | 2021 | International journal of bioprinting |
| Alave Reyes-Furrer, Angela and De Andrade, Sonia and Bachmann, Dominic and Jeker, Heidi and Steinmann, Martin and Accart, Nathalie and Dunbar, Andrew and Rausch, Martin and Bono, Epifania and Rimann, Markus and Keller, Hansjoerg | Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses | 2021 | Communications Biology |
| He, Shaolong and Radeke, Carmen and Jacobsen, Jette and Lind, Johan Ulrik and Mu, Huiling | Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir | 2021 | International Journal of Pharmaceutics |
| Asulin, Masha and Michael, Idan and Shapira, Assaf and Dvir, Tal | One-Step 3D Printing of Heart Patches with Built-In Electronics for Performance Regulation | 2021 | Advanced Science |
Manufacturer : regen HU
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| キーワード分類1 | Cell |
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| キーワード分類2 | Culture |
| キーワード分類3 | 3D printer |
| 製品カテゴリ1 | Device |
| 製品カテゴリ2 | Cell culture |
| 分野 | Drug discovery|Cancer|Regenerative medicine|Organ simulator|Biological imaging|Cell imaging |
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| 説明文 | Cost –effective 3D bio printing platform to explore the potential of 3D tissue engineering |
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| キーワード分類1 | Tissue |
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| 製品カテゴリ1 |
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| サムネイル画像 |
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| 説明文 | Cost –effective 3D bio printing platform to explore the potential of 3D tissue engineering |
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