MEPSGEN’s Microphysiological System (MEPS-TBC series)
Microphysiological System (MPS) use human cells and tissues to recapitulate the structure and function of human organ and enables the effective research and development of diseases and more accurate evaluation of new drugs
Key Features
- Our MPS replicates a wide range of human tissues and functions. This enables the development of comprehensive and realistic structure & function of human organ tissues for disease research and accurate drug evaluation.
- Utilizing advanced microfabrication technology and high-quality materials, our systemensures high precision and reproducibility.
- Users can adjust tissue types, configurations, and fluid flow to optimize experimental conditions.
- With a user-friendly interface and simple operation, our MPS is designed for ease of use.Users can operate the system without complex procedures or specialized knowledge.
MEPSGEN Microphysiological System(MPS): MEPS-X Series
MEPS-TBC-WL : 3D Tissue Barrier (lower well type)
- 2D-3D hybrid tissue-to-tissue barrier modeling
- Multiple cell and matrices loaded to recapitulate complex 3D human tissue architecture
- Physiological shear stress applicable in the upper channel
- High-precision barrier transport analysis only by diffusion to the sampling plate
- Applicable to the automated microphysiological system (ProMEPS™)
Application
MEPS-BBB
3D Blood-brain Barrier
MEPS-NVU
3D Neurovascular Unit
MEPS-HFU
3D Hepatic Functional Unit
MEPS-STL
3D Skin Tissue Layer
MEPS-TBC-CH : 2D Tissue Barrier (lower channel type)
- 2D-2D tissue-to-tissue barrier modeling
- Physiological shear stress applicable in the upper and bottom channel both simultaneously
- Applicable to the automated microphysiological system (ProMEPS™)
Application
MEPS-VEB
2D Vascular Endothelial Barrier
MEPS-SAW
2D Small Airway
MEPS-GFB
2D Glomerular Filtration Barrier
MEPS-TBC : 3D Tissue Barrier Chip Lab Scale
- Tissue-to-tissue barrier constructed by 2D-3D hybrid co-culture
- Physiological shear stress applicable
- High-precision sampling for drug testing and disease modeling
- Microfluidic compartments possible to disassemble for post cell analysis
Application
MEPS-VEB
2D Vascular Endothelial Barrier
MEPS-NVU
3D Neurovascular Unit
3D Blood-Brain Barrier
- Provides perfusion flow to the vascular endothelium
- Tri-cultured BBB cells
- 3D astrocyte culture with polarized end-feet processing
- Study the dynamic response of human cells to various drug administration conditions (time and dosage)
- Evaluate the permeability and mechanisms of the drug through the BBB
- Evaluate the targeting efficacy for brain cells like glia
Blood flow-induced shear stress on the endothelium
Interactions and communications of BBB cells (co-cultured)
Astrocytic end-feet processing (AQP4, …) with healthy astrocytes (3D) vs. reactive (2D)
3D microenvironment (ECM: colagen4, laminin, …)
References
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| キーワード分類1 | Cell |
|---|---|
| キーワード分類2 | Culture |
| キーワード分類3 | Microphysiological system |
| 製品カテゴリ1 | Consumables |
| 製品カテゴリ2 | Cell culture |
| 分野 | Drug discovery|Cancer|Regenerative medicine|Organ simulator|Personalized medicine |
| サムネイル画像 |
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| 説明文 | Discovery to Preclinical Human Testing:From Lab-scale Toward Automated Modeling System |
| リダイレクトURL |
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